Table Of Content
Two of the three expert reviewers in this area commented that HHT 's focus on biologics, working with Canadian SME s in the pre-clinical phase, is likely to lead to considerable or strong impacts. The third felt that this area of focus had the potential to lead to positive, yet moderate, impacts, given the size and structure of the industry in Canada. This expert also commented that the next few years could see changes in how the regulatory environment views biosimilars Footnote 20 and that HHT is well positioned, given the potential for future growth in this area. The relevance and performance of HHT 's three hosted programs are examined insofar as portfolio outcomes are achieved as a result of program activities.
Footnotes
I’m drawn to garments that feel comfortable, yet still offer something unique or interesting. Scroll through Artemis’ Instagram feed and you’ll be immediately swept away by wildly colorful loafers and slippers. Made from recycled Turkish rugs, Artemis’ vibrant and intricate products make you feel something. With regards to HHT 's contribution to client growth, a few clients specifically reported that their company has increased its number of employees since the beginning of the collaboration with NRC . Moreover, another client directly attributed the survival of the company to the services provided by NRC .
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Collaborations have been a cornerstone of our business and community building efforts with like minded companies and individuals. We make beautiful things in a slow and careful way, using a treasured team of artisan suppliers and cobblers to ensure that our chain of production is hands-on, handmade, and brings us as much pride as the products themselves. Upstate Rug Supply’s founder Joanna Mahserdjian was inspired to start her business after an interest in art history in college led her to begin collecting antique rugs. From a small capsule collection, Mahserdjian began traveling all over the US selecting rugs and eventually began Upstate Rug Supply. She specializes in hand-loomed Caucasian and Persian rugs (which covers present-day Iran, Azerbaijan, Armenia, and Turkey) made over 100 years ago, before the advent of machinery and synthetic dyes changed the craft.
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Other actions undertaken by the Portfolio in 2013‑14 include the updating of communications materials and of the NRC external website, as well as the publication of 20 print articles and third party press releases. With respect to the Vaccines Program, HHT organized the Canadian Adjuvant Initiative Workshop (March 2013) and continues to actively participate in the development of the Federal Research, Development and Innovation Vaccine Federal Action Plan. This action plan seeks to enhance communication among sector stakeholders (government, industry and academia) and to address identified Canadian vaccine and immunization priorities. Footnote 34 Internal and external stakeholders described these two activities as having been central to the Vaccines Program's strategic positioning within the industry, as well as to the broader vaccine innovation ecosystem. However, due to time and resource constraints, few efforts have been made to actively market these technologies to Canadian companies.
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Some internal and external interviewees also felt that IRAP Industrial Technology Advisors ( ITA s) could, when appropriate, play a stronger role in making their clients aware of the services being offered through HHT . However, the evaluation found that ITA s are generally not very familiar with HHT 's service offering, making it more difficult for them to identify opportunities where their clients could benefit from HHT services. HHT generally possesses the right technical and scientific competencies (people and research infrastructure) to achieve its expected outcomes. However, greater efforts are required to strengthen the leadership and business development skills of portfolio staff. The Office of Audit and Evaluation would like to gratefully acknowledge the management and staff of the Human Health Therapeutics ( HHT ) Portfolio for their support and contribution to this evaluation. We would also like to acknowledge the contribution of knowledge and expertise from other branches of NRC , including Finance, Business Management Support, Communications, Knowledge Management, and Planning and Reporting Services.
The evaluation found that there is strong industry endorsement with respect to HHT 's selected areas of focus. Most clients and expert reviewers agreed that HHT services are aligned with industry needs and one VC company representative confirmed that the kind of progress HHT aims to achieve when collaborating with clients is attractive to funders. At a federal level, the refocusing of NRC toward more industry-relevant R&D , with the aim of "helping the growth of innovative businesses in Canada" has been identified as a priority in both the 2012 and 2013 federal budgets. Moreover, the federal Science and Technology Strategy identifies "Health and related life sciences and technologies" as a priority area. At a time when any foible can now be airbrushed, edited, filtered or just plain omitted at will, the idea of imperfection as asset is a refreshing one.
HHT management and staff noted that the internal restructuring that has taken place over the past couple of years has led to significantly higher levels of efficiency and effectiveness. In line with the new matrix-based approach instituted at NRC , HHT has implemented its own matrix structure within the Portfolio. Expertise from across its three sites is now organized into four R&D departments, as well as an Operations department in which a project management office has been established. The pharmaceutical/ biopharmaceutical industry is important to the Canadian economy and HHT activities help to address some of the needs of biopharmaceutical SME s. Individual consultations (one-on-one interviews) with nine Canadian experts (i.e., three experts for each of the three programs) in the field of biopharmaceutical R&D were conducted in order to assess the relevance and performance of each program.
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The portfolio-hosted programs will undergo a more in-depth assessment as part of planned mid-term program reviews. It is expected that information drawn from this evaluation could contribute to the mid-term reviews. NRC corporate key performance indicators show a relatively high level of overhead efficiency and staff utilization.
The Process
The first is that some staff activities (for example, facility maintenance) are critical to portfolio operations but are categorized as an indirect expense. Secondly, there has been a significant learning curve with respect to NRC 's new time keeping and project management systems and HHT management suspects that some staff may still be entering time incorrectly. It is also worth noting that HHT 's staff utilization rate was the highest of the three life sciences portfolios and is the third highest among the 12 NRC portfolios. The evaluation found that, through its collaborations with private sector companies, HHT strongly contributed to the advancement and/or acceleration of therapeutic candidates, as this was an impact that was specifically identified by most of the clients interviewed. In particular, HHT 's strengths in the area of bioprocessing were frequently cited as having helped to increase the yield and purity of the material produced, often helping to overcome roadblocks the companies were facing in their product development.
While the role of BMS staff has been found to be critical in this area, HHT management clearly expressed the need to also increase the contribution of team leaders and other senior researchers in portfolio marketing activities. HHT management indicated that "team leaders need to become better ambassadors for the Portfolio", while also recognizing that significant training and coaching will be required before this group can fully embrace this new role. Some internal interviewees noted that despite the good progress that has been made to adopt a more industry-focused approach, remnants of an academic culture persists in some parts of the Portfolio. One interviewee estimated that it could take three to four more years before a complete culture change of this magnitude is realized. Recent efforts have been undertaken to increase the synergies between HHT and IRAP , including two meetings that were held in 2014 between HHT management and IRAP management/biomedical team staff. Many internal interviewees noted that ongoing engagement and sharing of information would be beneficial in order for ITA s to be able to more easily identify opportunities where their clients could benefit from HHT services.
The Vaccines Program came close to meeting its revenue targets for 2013‑14 and has been successful at providing research services to Canadian clients, particularly in areas of bioprocessing and analytics. However, a few key internal interviewees and some expert reviewers raised concerns about the Program's ability to establish strong co-development research agreements with Canadian industry. It is also worth noting that the Program draws a significant proportion of its revenues from Canadian non-industry and foreign sources. The case studies were selected in collaboration with HHT management and BMS staff and included projects for all three HHT -hosted programs.
This section describes the extent to which HHT has positioned itself to achieve its expected outcomes by examining the development of its core competencies and its level of engagement with industry clients. NRC has made the decision that it will not be offering cGMP services, as the set-up and operation of such a facility would be very resource-intensive and the organization feels that it is an area that is better served by the private sector. That said, HHT does recognize the need within the sector and is currently working with existing and potential contract manufacturing organizations ( CMO s) to help strengthen biomanufacturing in Canada. The Portfolio also proposes to act as a liaison, developing what it calls " cGMP -ready processes" and enabling its Canadian SME partners to successfully transfer their product manufacturing to a Canadian CMO . The HHT General Manager reports to the Vice-President, NRC Life Sciences, and has overall managerial accountability for the Portfolio. The Portfolio is organized into four R&D departments, each headed by an R&D director, as well as an Operations department responsible for quality control, process improvement, project management and coordination, and portfolio administrative support.
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